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Modern hyperthermia for modern radiotherapy

Cancer Centers Development

M&A

Global presence

ALBA

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M&A, Capital injection, JV's

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The SHI Team

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Hyperthermia

Radio-biological rationale

Boost up to 10 / 20 Gy or more with no additional toxicity

Heats tumors in the range of 41-43°C for 1 hour
Combined with radiotherapy or chemotherapy
Enhances the effect of radiotherapy & chemotherapy on the tumor, without additional toxicity
Effectively optimize clinical dose-fractionation schedules
1x / 2x a week

HT enhances the effectiveness of radiotherapy by inhibiting the repair of DNA damage.

HT increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity.

HT selectively kills radioresistant hypoxic tumor cells.

Datta et al Cancer Treat Rev. 2015;41:742-53
Datta et al Front Oncol 2020;10:819
Issels et al Int J Hyperthermia 2016;32:89-95
Oei et al Adv Drug Deliv Rev 2020;163-164:84-97

Inhibition of DNA damage repair

Reoxygenation

Direct cell killing

Local hyperthermia has also been shown to be capable of inducing systemic anti-tumor immune responses.

Franken, et al., 2013. Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology

Hyperthermia a clinical dose optimizer

Franken, et al., 2013. Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology

Higher thermo-dose

Hyperthermia dose escalation

cell survival is strongly dependent of thermo-radio sensitization modulation of the linear alfa and beta parameter of the lq model

High temperature & short time interval

Achievable as the units allow for a short preparation time and ultrafast and precise Hyperthermia treatment delivery.

Shorter time interval from RT beam off and HT (>41°C) within 1 hour

Higher temperature for reoxygenation and more direct cell killing for an effective thermodose escalation.

Short time interval

Higher temperature / dose

Sup and semi-deep hyperthermia system

Automatic focusing at tumor coordinates and optimal matching with heated tissue.

ALBA ON4000D

PRECISION

01

Superior SAR homogeneity and maximum power deposition in the target result in a high dose escalation.

HIGH THERMAL DOSE

03

Short preparation time of the patient set-up and dedicated tools for applicator positioning as well as the collimation of the center axis of the beam of the applicator with the center of the GTV/PTV.

FAST HYPERTHERMIA TREATMENT DELIVERY

02

Dedicated tools in full compliance with the guidelines of the European Society of Hyperthermic Oncology (ESHO) guarantees high level, quality hyperthermia treatment over time.

QUALITY ASSURANCE

04

Fully automated deep hyperthermia delivery

ALBA 4D

Good thermal contact to avoid artefacts